GDNF Receptor (胶质细胞源性神经营养因子受体)

Glial-cell-line-derived neurotrophic factor receptor (GDNF receptor) is a class of cell surface receptors that can specifically recognize and bind to GDNF. By binding to GDNF, it can initiate the intracellular signal transduction process, thereby regulating various biological functions of cells such as growth, differentiation, and survival. GDNF receptor can guide the migration and differentiation of neurons, facilitate the survival of neurons and axonal guidance, and is crucial for the construction of the nervous system. In addition, GDNF receptor has a neuroprotective effect, which can protect neurons from various damaging factors such as oxidative stress and inflammation, and enable neurons to resist degeneration. GDNF receptor is closely related to the degeneration of neurons in neurodegenerative diseases, also plays an important role in the repair of spinal cord and peripheral nerve injuries, and its abnormal expression is also associated with the occurrence, development, and metastasis of tumors such as neuroblastoma^[1][2].